| Identification | Back Directory | [Name]
Benzaldehyde, 4-(diethylamino)-3-nitro- | [CAS]
374635-48-0 | [Synonyms]
Akt1-IN-1
ALDH3A1-IN-2
Benzaldehyde, 4-(diethylamino)-3-nitro- | [Molecular Formula]
C11H14N2O3 | [MOL File]
374635-48-0.mol | [Molecular Weight]
222.24 |
| Chemical Properties | Back Directory | [Boiling point ]
360.3±37.0 °C(Predicted) | [density ]
1.208±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
0.92±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of ALDH3A1 with an IC50 of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases[1]. | [IC 50]
ALDH3 | [References]
[1] Ibrahim AIM, et al. Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem. 2022 Mar 10;65(5):3833-3848. DOI:10.1021/acs.jmedchem.1c01367 |
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