| Identification | Back Directory | [Name]
3-METHOXY-BENZENE-1,2-DIAMINE | [CAS]
37466-89-0 | [Synonyms]
NSC 521887
37466-89-0
hydrosulphate
2,3-DiaMinoanisol
2,3-Diaminoanisole
Esomeprazole Impurity 29
1,2-Diamino-3-methoxybenzene
3-Methoxy-1,2-benzenediamine
3-Methoxy-1,2-diaminobenzene
Methoxy-para-phenylenediaMine
3-METHOXY-BENZENE-1,2-DIAMINE
3-Methoxyphenylene-1,2-diamine
1,2-BenzenediaMine, 3-Methoxy-
3-Methoxy-1,2-phenylenediamine
3-Methoxy-o-phenylenediamine,97%
3-Methoxy-o-phenylenediaMine, 97% | [Molecular Formula]
C7H10N2O | [MDL Number]
MFCD08276903 | [MOL File]
37466-89-0.mol | [Molecular Weight]
138.17 |
| Chemical Properties | Back Directory | [Melting point ]
77-78℃ | [Boiling point ]
114-116 °C(Press: 0.5 Torr) | [density ]
1.170±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
solid | [pka]
4.10±0.10(Predicted) | [color ]
Black | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
37466-89-0 |
| Hazard Information | Back Directory | [Uses]
3-Methoxy-o-phenylenediamine is used as pharmaceutical intermediate. | [Synthesis]
General procedure for the synthesis of 1,2-diamino-3-methoxybenzene from 2-nitro-3-methoxyaniline: 5% palladium-carbon catalyst (18 mg, 20 wt%) was added to a solution of 2-nitro-3-methoxyaniline (90 mg, 0.54 mmol) in ethanol (3 mL). The reaction mixture was stirred at room temperature in a hydrogen atmosphere for 18 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was subsequently evaporated to afford the target product 3-methoxy-1,2-benzenediamine (73 mg, 100% yield). | [References]
[1] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 126
[2] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 11, p. 3441 - 3444
[3] Patent: EP2168959, 2010, A1. Location in patent: Page/Page column 121
[4] Patent: EP2168960, 2010, A1. Location in patent: Page/Page column 61-62
[5] Patent: US2011/301170, 2011, A1. Location in patent: Page/Page column 29 |
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