| Identification | Back Directory | [Name]
2-Chloro-4-ethoxy-6-methyl-pyrimidine | [CAS]
37482-64-7 | [Synonyms]
2-Chloro-4-ethoxy-6-methyl-pyrimidine
2-Chloro-4-ethoxy-6-methyl-pyrimidine ISO 9001：2015 REACH | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C7H9ClN2O | [MDL Number]
MFCD00234338 | [MOL File]
37482-64-7.mol | [Molecular Weight]
172.61 |
| Chemical Properties | Back Directory | [Melting point ]
70-73℃ | [Boiling point ]
282℃ | [density ]
1.193 | [Fp ]
124℃ | [storage temp. ]
Storage temp. 2-8°C | [pka]
0.76±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Uses]
2-Chloro-4-ethoxy-6-methylpyrimidine is a reactant/starting material in the preparation of azolylpyrimidines as cytoprotective antiulcer agents. | [Synthesis]
General procedure: 2,4-dichloro-6-methylpyrimidine (3.0 g, 18.4 mmol), cesium carbonate (Cs2CO3, 6.6 g, 20.2 mmol) and ethanol (EtOH, 46 mL) were added to a reaction flask, and the mixture was stirred under reflux conditions for 48 hours. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was purified by column chromatography to afford the target product 2-chloro-4-ethoxy-6-methylpyrimidine (1.88 g, 59% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ6.47 (1H, s), 4.41 (2H, q), 2.42 (3H, s), 1.39 (3H, t). | [References]
[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0476
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5206 - 5220
[3] Patent: WO2016/133959, 2016, A1. Location in patent: Page/Page column 46; 47 |
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| Company Name: |
BePharm Ltd
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400-685-9117 |
| Website: |
www.bepharm.com |
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cjbscvictory
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13348960310 13348960310 |
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www.weikeqi-biotech.com/ |
| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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