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374913-63-0

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374913-63-0 Structure

374913-63-0 Structure
IdentificationBack Directory
[Name]

Madrasin
[CAS]

374913-63-0
[Synonyms]

CS-2251
Madrasin
DD00107587
DDD00107587
DDD-00107587
Madrasin >=98% (HPLC)
DDD00107587;DD00107587;DDD-00107587
4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-
[Molecular Formula]

C16H17N5O2
[MDL Number]

MFCD02233199
[MOL File]

374913-63-0.mol
[Molecular Weight]

311.34
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO:1.5(Max Conc. mg/mL);4.82(Max Conc. mM)
[form ]

powder
[color ]

white to dark brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302
[Precautionary statements ]

P301+P312+P330
Hazard InformationBack Directory
[Uses]

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.
[Definition]

ChEBI: 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one is a member of quinazolines.
[Biochem/physiol Actions]

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Madrasin(374913-63-0)1HNMR
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