| Identification | Back Directory | [Name]
JNJ-10258859 | [CAS]
374927-03-4 | [Synonyms]
JNJ-10258859
UNII-4NPX9224XR
9H-Pyrrolo[3,4-b]quinolin-9-one, 3-(2,3-dihydro-5-benzofuranyl)-1,2,3,4-tetrahydro-2-[5-(4-methoxyphenyl)-2-pyrimidinyl]-, (3R)- | [Molecular Formula]
C30H24N4O3 | [MDL Number]
MFCD05260959 | [MOL File]
374927-03-4.mol | [Molecular Weight]
488.54 |
| Hazard Information | Back Directory | [Uses]
JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a Ki of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research[1]. | [IC 50]
PDE5: 0.23±0.03 nM (Ki); PDE4: 5.01±1.88 μM (Ki); PDE3: 9.67±1.95 μM (Ki); PDE2: 25.33±5.53 μM (Ki); PDE1: >100 μM (Ki) | [References]
[1] Qiu Y, et al. Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859. Eur J Pharmacol. 2003 Jul 4;472(1-2):73-80. DOI:10.1016/s0014-2999(03)01868-5 |
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