| Identification | Back Directory | [Name]
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione | [CAS]
37538-68-4 | [Synonyms]
2,4-Dihydroxypyrido[3,2-d]pyriMidine
1H-Pyrido[3,2-d]pyrimidine-2,4-dione
1H,3H-Pyrido[3,2-d]pyriMidine-2,4-dione
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
1H,2H,3H,4H-pyrido[3,2-d]pyriMidine-2,4-dione | [Molecular Formula]
C7H5N3O2 | [MDL Number]
MFCD13185173 | [MOL File]
37538-68-4.mol | [Molecular Weight]
163.13 |
| Hazard Information | Back Directory | [Uses]
2,4-Dihydroxypyrido[3,2-d]pyrimidine is used as a reagent in the synthesis of diaminoquinazolines as antitubercular agents. 2,4-Dihydroxypyrido[3,2-d]pyrimidine may also be used as a potential histamine H4 receptor antagonist. | [Synthesis]
(1) 4 g of 3-aminopyridine-2-carboxylic acid (raw material A3) was mixed with 20 g of urea and heated and refluxed at 200°C for 5 h. After the reaction was completed, intermediate B3 was obtained in 27% yield. The reaction equation was as follows: | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2663 - 2670
[2] Patent: CN106083742, 2016, A. Location in patent: Paragraph 0185; 0186; 0187
[3] Journal of the Chemical Society, 1956, p. 1045,1053 |
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