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375822-19-8

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375822-19-8 Structure

375822-19-8 Structure
IdentificationBack Directory
[Name]

D-Ala-Lys-AMCA
[CAS]

375822-19-8
[Synonyms]

D-Ala-Lys-AMCA
L-Lysine, D-alanyl-N6-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-yl)acetyl]- (9CI)
[Molecular Formula]

C21H28N4O6
[MDL Number]

MFCD32062745
[MOL File]

375822-19-8.mol
[Molecular Weight]

432.47
Chemical PropertiesBack Directory
[Boiling point ]

826.2±65.0 °C(Predicted)
[density ]

1.300±0.06 g/cm3(Predicted)
[pka]

3.15±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

D-Ala-Lys-AMCA is a known proton-coupled oligopeptide transporter 1 (PEPT1) substrate that emits blue fluorescence. D-Ala-Lys-AMCA may be transported into liver cancer cells and Caco-2 cells based on fluorescence analysis. D-Ala-Lys-AMCA can be used for characterizing PEPT1-specific substrates or inhibitors[1][2].
[References]

[1] Gong Y, et al. Specific expression of proton-coupled oligopeptide transporter 1 in primary hepatocarcinoma-anovel strategy for tumor-targeted therapy. Oncol Lett. 2017 Oct;14(4):4158-4166. DOI:10.3892/ol.2017.6724
[2] Groneberg DA, et al. Intestinal peptide transport: ex vivo uptake studies and localization of peptide carrier PEPT1. Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G697-704. DOI:10.1152/ajpgi.2001.281.3.G697
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