| Identification | Back Directory | [Name]
methyl 3-(2-(4-benzylpiperazin-1-yl)acetamido)-5-chloro-1H-indole-2-carboxylate | [CAS]
375835-04-4 | [Synonyms]
XIAP antagonist 1
methyl 3-(2-(4-benzylpiperazin-1-yl)acetamido)-5-chloro-1H-indole-2-carboxylate
1H-Indole-2-carboxylic acid, 5-chloro-3-[[2-[4-(phenylmethyl)-1-piperazinyl]acetyl]amino]-, methyl ester | [Molecular Formula]
C23H25ClN4O3 | [MOL File]
375835-04-4.mol | [Molecular Weight]
440.92 |
| Hazard Information | Back Directory | [Uses]
XIAP antagonist 1 degrades rather than inhibits XIAP, catalyzing rapid degradation of XIAP through the ubiquitin-proteasome pathway[1][2]. | [References]
[1] Dana Mamriev, et al. A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2. Cell Death Dis. 2020 Jun 25;11(6):483. DOI:10.1038/s41419-020-2670-2
[2] Zhang'E Choo, et al. Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma. Cancer Res Commun. 2023 Nov 22;3(11):2386-2399. DOI:10.1158/2767-9764.CRC-23-0082 |
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