| Identification | Back Directory | [Name]
5-CYCLOHEXADECEN-1-ONE | [CAS]
37609-25-9 | [Synonyms]
VELVIONE
AMBRETONE
musk amberol
Cyclohexadeceneone
5-Cyclohexadecenone
5-Cyclohexadecen-1-on
5-CYCLOHEXADECEN-1-ONE
5-Cyclohexadecene-1-one
Cyclohexadecen-1-one,5-
(E)-cyclohexadec-5-enone
5-Cyclohexadecen-1-one>
5-CYCLOHEXADECEN-1-ONE 95+% | [EINECS(EC#)]
253-568-9 | [Molecular Formula]
C16H28O | [MDL Number]
MFCD00059511 | [MOL File]
37609-25-9.mol | [Molecular Weight]
236.39 |
| Chemical Properties | Back Directory | [Melting point ]
25 °C | [Boiling point ]
120 °C / 1mmHg | [density ]
0.93 | [vapor pressure ]
0.02Pa at 20℃ | [Fp ]
166 °C | [form ]
Liquid | [color ]
White to Almost white | [Odor]
at 10.00 % in dipropylene glycol. dry powdery musk amber civet | [Odor Type]
musk | [Cosmetics Ingredients Functions]
PERFUMING | [InChI]
1S/C16H28O/c17-16-14-12-10-8-6-4-2-1-3-5-7-9-11-13-15-16/h6,8H,1-5,7,9-15H2/b8-6- | [InChIKey]
ABRIMXGLNHCLIP-VURMDHGXSA-N | [SMILES]
O=C1CCCCCCCCCCC=CCCC1 | [LogP]
5.8-6.4 at 20-35℃ and pH7-7.2 | [EPA Substance Registry System]
5-Cyclohexadecen-1-one (37609-25-9) |
| Safety Data | Back Directory | [WGK Germany ]
WGK 2 | [TSCA ]
TSCA listed | [HS Code ]
2914.29.5000 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Chemical Properties]
5-CYCLOHEXADECEN-1-ONE is commercially available as a
40 : 60 mixture of its (Z)- and (E)-isomers. It is a colorless liquid with an intense
musk odor.
A three-step synthesis starts from cyclododecanone. Reaction with chlorine
gives 2-chlorocyclododecanone, which is reacted with 2 mol of vinyl magnesium
chloride to give 1,2-divinylcyclododecan-l-ol. This is finally converted into
5-cyclohexadecen-1-one by an oxy-Cope rearrangement.
5-Cyclohexadecen-l-one can be added to perfume compositions as a substitute
for the natural macrocyclic ketone musks： | [Trade name]
Musk TM-II (Soda Aromatic), Velvione® (Givaudan),
Ambretone® (Takasago) |
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