| Identification | Back Directory | [Name]
BVT-14225 | [CAS]
376638-65-2 | [Synonyms]
BVT-14225
BVT-14225, >98%
BVT14225;BVT 14225
4-Thiazoleacetamide,2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl- | [Molecular Formula]
C16H20ClN3O3S2 | [MDL Number]
MFCD25976913 | [MOL File]
376638-65-2.mol | [Molecular Weight]
401.93 |
| Chemical Properties | Back Directory | [Boiling point ]
586.5±60.0 °C(Predicted) | [density ]
1.373±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 27 mg/mL (67.18 mM) | [form ]
Solid | [pka]
6.34±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM. | [References]
[1] Barf T, et al. Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2002 Aug 29;45(18):3813-5. DOI:10.1021/jm025530f
[2] Vicker N, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9. DOI:10.1016/j.jsbmb.2007.03.023 |
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