| Identification | Back Directory | [Name]
11-DEOXY PROSTAGLANDIN E1 | [CAS]
37786-00-8 | [Synonyms]
11-DEOXY PROSTAGLANDIN E1
11-deoxy Prostaglandin E1 Exclusive
9-OXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID
7-((1R,2R)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid | [Molecular Formula]
C20H34O4 | [MDL Number]
MFCD00065738 | [MOL File]
37786-00-8.mol | [Molecular Weight]
338.48 |
| Chemical Properties | Back Directory | [Boiling point ]
509.7±35.0 °C(Predicted) | [density ]
1.070±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1) | [form ]
A crystalline solid | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs[1]. | [Definition]
ChEBI: 11-deoxyprostaglandin E1 is a prostanoid. | [in vivo]
11-Deoxy prostaglandin E1 (administered as a spray) has no significant bronchodilator effect in guinea pigs and cats[1].
| [storage]
Store at -20°C | [References]
[1] Greenberg R, et al. The bronchodilator acitivity of an 11-deoxyprostaglandin (AY 23 578). Can J Physiol Pharmacol. 1975 Oct;53(5):799-809. DOI:10.1139/y75-110 |
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