| Identification | Back Directory | [Name]
11-DEOXY PROSTAGLANDIN F2ALPHA | [CAS]
37786-06-4 | [Synonyms]
11-deoxyPGF2a
11-deoxy-PGF2a
11-deoxy PGF2a
11-Deoxyprostaglandin F2α
11-deoxy-Prostaglandin F2a
11-deoxy Prostaglandin F2α
YRFLKMLJQWGIIZ-APRRXLQMSA-N
1-deoxy Prostaglandin F2alpha
11-DEOXY PROSTAGLANDIN F2ALPHA
1-deoxy Prostaglandin F2α
11deoxyPGF2a,11-deoxy-PGF-2a,11 deoxy PGF2a
9ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID | [Molecular Formula]
C20H34O4 | [MDL Number]
MFCD00797656 | [MOL File]
37786-06-4.mol | [Molecular Weight]
338.48 |
| Chemical Properties | Back Directory | [Boiling point ]
511.4±45.0 °C(Predicted) | [density ]
1.090±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a) | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
11-deoxy PGF2α is a synthetic analog of PGF2α. It is a more potent agonist than PGF2α at inducing smooth muscle contractions of rabbit aorta, dog saphenous vein, and guinea pig trachea. It is approximately 20% less potent than U-46619. | [Uses]
11-Deoxyprostaglandin F2α is an activator for TREK-2 channels with EC50 of 0.294 μM. 11-Deoxyprostaglandin F2α inhibits the K2P channel TREK-1[1]. | [storage]
Store at -20°C | [References]
[1] Dadi PK,et al., Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx. ACS Chem Neurosci. 2017 Mar 15;8(3):558-568. DOI:10.1021/acschemneuro.6b00301 |
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