| Identification | Back Directory | [Name]
(5E,9E,13E)-6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one | [CAS]
3796-63-2 | [Synonyms]
E-0671
(5E,9E,13E)-Geranylgeranylacetone
(5E,9E,13E)-6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one
5,9,13,17-Nonadecatetraen-2-one, 6,10,14,18-tetramethyl-, (E,E,E)-
(5E,9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
5,9,13,17-Nonadecatetraen-2-one, 6,10,14,18-tetramethyl-, (5E,9E,13E)- | [Molecular Formula]
C23H38O | [MOL File]
3796-63-2.mol | [Molecular Weight]
330.55 |
| Chemical Properties | Back Directory | [Boiling point ]
442.2±24.0 °C(Predicted) | [density ]
0.872±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (15.13 mM) | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
(5E,9E,13E)-Teprenone is an isomer of Teprenone (T103500), An anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. | [Definition]
ChEBI: Teprenone is a terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio). It has a role as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. It is a methyl ketone and a terpene ketone. It contains a geranylgeranyl group. | [in vivo]
(5E,9E,13E)-Teprenone induces hat sock proteins accumulations in rat gastric mucosa[1].
| Animal Model: | Male Wister strain rats (≈250 g)[1] | | Dosage: | 200 mg/kg | | Administration: | Oral administration | | Result: | Caused accumulations of all of HSP90, HSP70, HSC70 and HSP60 within 60 minutes. |
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