| Identification | Back Directory | [Name]
LM 22A4 | [CAS]
37988-18-4 | [Synonyms]
BD2-4
LM 22A4
LM 22A4; LM 22A-4
N,N',N''-Tris(beta-hydroxyethyl)trimesamide
N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-
1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE | [Molecular Formula]
C15H21N3O6 | [MDL Number]
MFCD00382831 | [MOL File]
37988-18-4.mol | [Molecular Weight]
339.34 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble2mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. | [InChI]
1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24) | [InChIKey]
RGWJKANXFYJKHN-UHFFFAOYSA-N | [SMILES]
N(CCO)C(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO |
| Hazard Information | Back Directory | [Description]
LM22A-4 (37988-18-4) is a small molecule BDNF mimetic displaying neurotrophhic activity. Partial agonist at TRKB and activates TRKB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administraton, LM22A-4 caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats.1?Improves respiratory function in a mouse models of Rett syndrome.2 | [Uses]
LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. LM 22A4 has been show to induce activation of Trk, Akt and ERK in mouse hippocampus and striatum and reverse deficits in motor task learning in mice following traumatic brain injury. LM 22A4 also restored respiratory function in a rat model of Rett syndrome. | [in vivo]
LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals[1]. | [storage]
Store at -20°C | [References]
1) Massa et al. (2010), Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents; J. Clin. Invest., 120 1774
2) Schmid et al. (2012), A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome; J. Neurosci., 32 1803 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
|