| Identification | Back Directory | [Name]
BETA-D-RIBOFURANURONAMIDE, 1-DEOXY-1-[6-[(2,2-DIPHENYLETHYL)AMINO]-2-[[[2-[[[[1-(2-PYRIDINYL)-4-PIPERIDINYL]AMINO]CARBONYL]AMINO]ETHYL]AMINO]CARBONYL]-9H-PURIN-9-YL]-N-ETHYL- | [CAS]
380221-63-6 | [Synonyms]
UK 432097
UK-432097 >=98% (HPLC)
β-D-Ribofuranuronamide, 1-deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[[[2-[[[[1-(2-pyridinyl)-4-piperidinyl]amino]carbonyl]amino]ethyl]amino]carbonyl]-9H-purin-9-yl]-N-ethyl-
BETA-D-RIBOFURANURONAMIDE, 1-DEOXY-1-[6-[(2,2-DIPHENYLETHYL)AMINO]-2-[[[2-[[[[1-(2-PYRIDINYL)-4-PIPERIDINYL]AMINO]CARBONYL]AMINO]ETHYL]AMINO]CARBONYL]-9H-PURIN-9-YL]-N-ETHYL- | [Molecular Formula]
C40H47N11O6 | [MDL Number]
MFCD28137759 | [MOL File]
380221-63-6.mol | [Molecular Weight]
777.89 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [pka]
9.85±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UK-432097 is a highly potent and selective A2AAR agonist with a pKi of 8.4 for human A2AAR. UK-432097 has anti-inflammatory and anti-aggregatory properties. UK-432097 has the potential for COPD (Chronic Obstructive Pulmonary Disease) research[1][2][3]. | [Biological Activity]
UK-432097 is a selective adenosine receptor A2AAR full agonist with EC50 of 0.66 ± 0.19 nM. It was recently used to map the structure of the active state of the adenosine A2A receptor. | [References]
[1] Fei Xu, et al. Structure of an agonist-bound human A2A adenosine receptor. Science. 2011 Apr 15;332(6027):322-7. DOI:10.1126/science.1202793
[2] Kenneth A Jacobson, et al. Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development. Front Cell Neurosci. 2019 Mar 28;13:124. DOI:10.3389/fncel.2019.00124
[3] J Daniel Hothersall, et al. Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics. Mol Pharmacol. 2017 Jan;91(1):25-38. DOI:10.1124/mol.116.105551 |
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