| Identification | Back Directory | [Name]
streptothricin F | [CAS]
3808-42-2 | [Synonyms]
Yazumycin A
BRN 6031385
Racemomycin A
streptothricin F
Streptothricin VI
Antibiotic S-15-1A
(3aS)-2-[[4-O-(Aminocarbonyl)-2-[[(S)-3,6-diamino-1-oxohexyl]amino]-2-deoxy-β-D-gulopyranosyl]amino]-1,3aβ,5,6,7,7aα-hexahydro-7β-hydroxy-4H-imidazo[4,5-c]pyridin-4-one
4H-Imidazo[4,5-c]pyridin-4-one, 2-[[4-O-(aminocarbonyl)-2-deoxy-2-[[(3S)-3,6-diamino-1-oxohexyl]amino]-β-D-gulopyranosyl]amino]-1,3a,5,6,7,7a-hexahydro-7-hydroxy-, (3aS,7R,7aS)- | [Molecular Formula]
C19H34N8O8 | [MDL Number]
MFCD01939650 | [MOL File]
3808-42-2.mol | [Molecular Weight]
502.526 |
| Chemical Properties | Back Directory | [Boiling point ]
592.64°C (rough estimate) | [density ]
1.3824 (rough estimate) | [refractive index ]
1.6910 (estimate) | [pka]
12.66±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Streptothricin F is a bactericidal antibiotic. Streptothricin F interacts with the 30S subunit of 70S ribosome. Streptothricin F shows rapid, bactericidal activity against highly drug-resistant, carbapenem-resistant Enterobacterales (CRE) (MIC50 and MIC90: 2 and 4 μM, respectively) and Acinetobacter baumannii[1]. | [Definition]
ChEBI: A streptothricin in which the peptide side-chain consists of a single unit of beta-lysine. | [References]
[1] Morgan CE, et al. Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. PLoS Biol. 2023 May 16;21(5):e3002091. DOI:10.1371/journal.pbio.3002091 |
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