| Identification | Back Directory | [Name]
DIPHENOXYLATE HYDROCHLORIDE | [CAS]
3810-80-8 | [Synonyms]
r1132
DIPHENOXYLATE HCL
DIPHENOXYLATE HYDROCHLORIDE
Diphenoxylate for system suitability
Diphenoxylate hydrochloride solution
Diphenoxylate Hydrochloride CII (200 mg)
Diphenoxylate HCL (Subj To Narcotic Permit)
DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION
DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI
Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
Diphenoxylate Hydrochloride CII (200 mg)I1D3390.998mg/mg(dr)
1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecoticacidethylesterhydrochl
ethyl1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotatemonohydrochloride
isonipecoticacid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,ethylester,hydro
4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride
Diphenoxylate HydrochlorideQ: What is
Diphenoxylate Hydrochloride Q: What is the CAS Number of
Diphenoxylate Hydrochloride Q: What is the storage condition of
Diphenoxylate Hydrochloride | [EINECS(EC#)]
223-287-6 | [Molecular Formula]
C30H33ClN2O2 | [MDL Number]
MFCD00058213 | [MOL File]
3810-80-8.mol | [Molecular Weight]
489.05 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
220.5-222° | [storage temp. ]
-20°C | [solubility ]
Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent). | [form ]
Solid | [color ]
White to Off-White | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C30H32N2O2.ClH/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27;/h3-17H,2,18-23H2,1H3;1H | [InChIKey]
SHTAFWKOISOCBI-UHFFFAOYSA-N | [SMILES]
[Cl-].N3(CCC(CC3)(c4ccccc4)C(=O)OCC)CCC(c2ccccc2)(c1ccccc1)C#N.[H+] |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
Antiperistaltic; antidiarrheal.
Controlled substance (opiate). | [Definition]
ChEBI: The hydrochloride salt of diphenoxylate. | [Originator]
Lomotil,Searle,US,1960 | [Manufacturing Process]
A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15
parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for
24 hours at 100-120°C and then cooled and filtered to remove the precipitate
of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The
filtrate is then extracted with dilute hydrochloric acid and the extract is
rendered alkaline by addition of concentrated aqueous potassium hydroxide
and extracted with ether. This ether extract is treated with gaseous hydrogen
chloride. The resulting precipitate is collected on a filter. The hydrochloride of
the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'-
piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See
meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl
ester. | [Therapeutic Function]
Antidiarrheal | [Veterinary Drugs and Treatments]
Diphenoxylate is an opiate in combination with atropine in antidiarrheal
products used primarily in dogs; it also has antitussive
properties. Use in cats is controversial and many clinicians do not
recommend its use in this species. |
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