| Chemical Properties | Back Directory | [Melting point ]
>300 °C (decomp) | [solubility ]
DMSO, acetonitrile, methanol | [form ]
Solid | [color ]
White to off-white | [Appearance]
white crystals |
| Hazard Information | Back Directory | [Description]
Tetraglycine, or Gly-Gly-Gly-Gly, is an oligopeptide composed of four glycine monomers. It is used as a bifunctional linker with amino and carboxyl groups .
The terminal amino group can react with activated esters, carbonyl compounds, and carboxylic acids, e.g., in reductive amination reactions.
The terminal carboxyl group can react with primary amino groups in the presence of activators (carbodiimides or HATU), resulting in a stable amide bond. | [Uses]
Tetraglycine hydrochloride is a oligopeptide composed of four glycine monomers[1]. | [in vivo]
Tetraglycine and Triglycine (1.0 μmol glycine/g body wt (246.22 mg/kg), injected into a central vein) results in greater glycine concentration in the kidney than injection of either Glycine (HY-Y0966) or Diglycine[1]. | Animal Model: | Male Sprague-Dawley rats (270-300 g)[1] | | Dosage: | 1.0 μmol glycine/g body wt (246.22 mg/kg) | | Administration: | IV, injected over a period of 30 s | | Result: | Five minutes after the Tetraglycine injection, there were accumulations of diglvcine, triglvcine, and Tetraglycine in the kidney. |
| [References]
[1] Adibi SA, et al. Enrichment of glycine pool in plasma and tissues by glycine, di-, tri-, and tetraglycine. Am J Physiol. 1982 Nov;243(5):E413-7. DOI:10.1152/ajpendo.1982.243.5.E413 |
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