| Identification | Back Directory | [Name]
(E)-Ethyl 3-(4-(benzyloxy)-3-Methoxyphenyl)acrylate | [CAS]
38157-08-3 | [Synonyms]
(E)-Ethyl 3-(4-(benzyloxy)-3-Methoxyphenyl)acrylate
(E)-3-(4-benzyloxy-3-methoxyphenyl)acrylic acid ethyl ester
2-Propenoic acid, 3-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester,(2E)- | [Molecular Formula]
C19H20O4 | [MDL Number]
MFCD00228704 | [MOL File]
38157-08-3.mol | [Molecular Weight]
312.36 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: Ethoxycarbonylmethylenetriphenylphosphine (1.55 g, 4.46 mmol) was added to a stirred solution of 4-benzyloxy-3-methoxybenzaldehyde (0.73 g, 3.72 mmol) in benzene (10 mL). The reaction mixture was then refluxed for 4 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether, 1:19) to afford the target product ethyl (E)-3-(4-(benzyloxy)-3-methoxyphenyl)acrylate (0.89 g, 90% yield) as a white solid. | [References]
[1] European Journal of Organic Chemistry, 2015, vol. 2015, # 33, p. 7344 - 7351
[2] Tetrahedron Asymmetry, 2011, vol. 22, # 24, p. 2124 - 2133
[3] Turkish Journal of Chemistry, 2010, vol. 34, # 3, p. 375 - 380
[4] Mendeleev Communications, 2010, vol. 20, # 3, p. 151 - 152
[5] Chemical Papers, 2010, vol. 64, # 5, p. 630 - 636 |
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