| Identification | Back Directory | [Name]
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride | [CAS]
38176-02-2 | [Synonyms]
LU 33925
NSC 632821
Dexverapamil monohydrochloride
R(+)-Verapamil monohydrochloride
R(+)-Verapamil monohydrochloride hydrate
R(+)-Verapamil hydrate monohydrochloride
R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
(+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6-
(αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride
Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (R)-
Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI)
Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (R)-
Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)- | [EINECS(EC#)]
253-810-3 | [Molecular Formula]
C27H41ClN2O5 | [MDL Number]
MFCD11046028 | [MOL File]
38176-02-2.mol | [Molecular Weight]
509.078 |
| Chemical Properties | Back Directory | [Appearance]
Colourless solid | [Melting point ]
129-131?C | [storage temp. ]
Refrigerator | [solubility ]
H2O: >30mg/mL | [form ]
powder | [color ]
white | [Optical Rotation]
[α]22/D +9.6°, c = 0.5 in ethanol(lit.) | [Water Solubility ]
H2O: >30mg/mL
ethanol: soluble | [InChIKey]
ICKXRKHJKXMFLR-KFSCGDPASA-N | [SMILES]
O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless solid | [Uses]
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells. | [Definition]
ChEBI: Dexverapamil hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. It has a role as an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It contains a dexverapamil(1+). It is an enantiomer of a (S)-verapamil hydrochloride. | [Biochem/physiol Actions]
Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25 | [Safety Statements ]
22-36/37/39-45 | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral |
|
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Sigma-Aldrich
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