| Identification | Back Directory | [Name]
2-Fluoro-3-Chloro-5-Bromopyridine | [CAS]
38185-56-7 | [Synonyms]
2-Fluoro-3-Chloro-5-Bromopyridine
3-BROMO-5-CHLORO-6-FLUOROPYRIDINE
5-Bromo-3-chloro-2-fluoropyridine 98% | [Molecular Formula]
C5H2BrClFN | [MDL Number]
MFCD09834365 | [MOL File]
38185-56-7.mol | [Molecular Weight]
210.431 |
| Chemical Properties | Back Directory | [Melting point ]
60℃ | [Boiling point ]
206.3±35.0 °C(Predicted) | [density ]
1.829±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerated. | [form ]
Solid | [pka]
-5.07±0.20(Predicted) | [Appearance]
White to off-white Solid | [CAS DataBase Reference]
38185-56-7 |
| Hazard Information | Back Directory | [Uses]
5-Bromo-3-chloro-2-fluoropyridine is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research. | [Synthesis]
2) The reaction system was cooled in an ice bath, followed by the slow addition of sodium nitrite (4.8 g, 70 mmol) to a solution consisting of the above amine product (12.6 g, 61 mmol) dissolved in hydrogen fluoride/pyridine (70% HF, 91 ml). The reaction mixture was stirred continuously for 30 min at room temperature. After completion of the reaction, ice was added to the reaction solution and neutralized with sodium carbonate solution. Subsequently, the organic layer was separated by extraction with ether. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure to remove the solvent. The crude product obtained was further purified by silica gel column chromatography (eluent ratio hexane:ethyl acetate=80:20) to afford the target compound 5-bromo-3-chloro-2-fluoropyridine (11.1 g, 87% yield) as a white solid. | [References]
[1] Patent: EP2221301, 2010, A1. Location in patent: Page/Page column 46
[2] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 143-144 |
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