| Identification | Back Directory | [Name]
(2R,3R,4S,5S,6R)-2-((8-(2-aMino-6-((4-broMothiophen-2-yl)Methoxy)-9H-purin-9-yl)octyl)oxy)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol | [CAS]
382607-78-5 | [Synonyms]
O6BTG-C8-βGlu
O6BTG-octylglucoside
Glucose-conjugated MGMT inhibitor
β-D-Glucopyranoside, 8-[2-aMino-6-[(4-broMo-2-thienyl)Methoxy]-9H-purin-9-yl]octyl
8-[2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purin-9-yl]octyl beta-D-glucopyranoside
(2R,3R,4S,5S,6R)-2-[8-[2-amino-6-[(4-bromothiophen-2-yl)methoxy]purin-9-yl]octoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
(2R,3R,4S,5S,6R)-2-((8-(2-aMino-6-((4-broMothiophen-2-yl)Methoxy)-9H-purin-9-yl)octyl)oxy)-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol | [Molecular Formula]
C24H34BrN5O7S | [MDL Number]
MFCD22124457 | [MOL File]
382607-78-5.mol | [Molecular Weight]
616.53 |
| Chemical Properties | Back Directory | [Boiling point ]
847.4±75.0 °C(Predicted) | [density ]
1.70 | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (162.20 mM; Need ultrasonic) | [form ]
Powder | [pka]
12.95±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. | [IC 50]
MGMT: 32 nM (IC50) | [References]
[1] Jost Reinhard, et al. Inactivation of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors. Int.J.Cancer. (2001) 93,373-379. |
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| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
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