| Identification | Back Directory | [Name]
6-Bromo-4-chloroquinazoline | [CAS]
38267-96-8 | [Synonyms]
4-Chloro-6-bromoquinazoline
6-BROMO-4-CHLOROQUINAZOLINE
6-Bromo-4-chloroquinazoli...
6-BROMO-4-CHLOROQUINAZOLINE, 95+%
6-Bromo-4-chloro-quinazoline hydrochloride
6-Bromo-4-chloroquinazoline ISO 9001：2015 REACH | [EINECS(EC#)]
202-766-3 | [Molecular Formula]
C8H4BrClN2 | [MDL Number]
MFCD01862191 | [MOL File]
38267-96-8.mol | [Molecular Weight]
243.49 |
| Chemical Properties | Back Directory | [Melting point ]
160-163 °C | [Boiling point ]
339.7±22.0 °C(Predicted) | [density ]
1.763 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
0.07±0.30(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-chloro-6-bromoquinazoline from 6-bromo-3H-quinazolin-4-one (20 g, 89 mmol): 6-bromo-3H-quinazolin-4-one was suspended in 140 mL of phosphorus oxychloride (POCl3), and the reaction was stirred for 3 hr at 140 °C. After completion of the reaction, the reaction mixture was concentrated under vacuum and the residue was dissolved in 500 mL of dichloromethane (CH2Cl2). The reaction solution was neutralized with 200 g of solid sodium bicarbonate (NaHCO3), filtered, and the filtrate was evaporated under vacuum to afford 4-chloro-6-bromoquinazoline (21 g, 95% yield) as a beige solid. The product was characterized by 1H-NMR (400 MHz, CDCl3, 298 K): δ 7.98 (d, 1H), 8.09 (d, 1H), 8.5 (s, 1H), 9.1 (s, 1H). Mass spectrometry (MS) analysis showed [M + 1]+ m/z 243.0-244.9, retention time (Rt) = 1.24 min. | [References]
[1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 186
[3] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0974-0975
[4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 8, p. 762 - 767
[5] Patent: TWI557109, 2016, B. Location in patent: Page/Page column 48; 49; 83 |
|
|