| Identification | Back Directory | [Name]
benurestat | [CAS]
38274-54-3 | [Synonyms]
EU-2826
benurestat
p-Chlorohippurohydroxamic Acid
4-Chloro-N-(2-(hydroxyamino)-2-oxoethyl)benzamide
Benzamide, 4-chloro-N-[2-(hydroxyamino)-2-oxoethyl]-
Urease,Bacterial,ammonia,inhibit,Benurestat,Inhibitor | [Molecular Formula]
C9H9ClN2O3 | [MDL Number]
MFCD00868211 | [MOL File]
38274-54-3.mol | [Molecular Weight]
228.63 |
| Hazard Information | Back Directory | [Uses]
Enzyme inhibitor (urease). | [Uses]
p-Chlorohippurohydroxamic Acid is a potent inhibitor of recombinant human glutathione transferase P1-1. | [Definition]
ChEBI: Benurestat is a N-acylglycine. | [in vivo]
Benurestat administration, 25 mg/kg, 50 mg/kg, or 100 mg/kg, causes a decrease in the urinary excretion of ammonia from rats with experimental P. mirabilis genitourinary tract infection[1].
The number of viable bacteria present in the bladders of infected rats is significantly less after the administration of Benurestat plus Nitrofurantoin, Sulfamethoxazole, or Ampicillin than the respective numbers that are obtained from control infected rats or from rats administered either component of the combination separately[1]. |
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