| Identification | Back Directory | [Name]
PNU 288034 | [CAS]
383199-88-0 | [Synonyms]
PNU 288034
Acetamide, N-[[(5S)-3-[4-(1,1-dioxido-4-thiomorpholinyl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]- | [Molecular Formula]
C16H19F2N3O5S | [MDL Number]
MFCD13248649 | [MOL File]
383199-88-0.mol | [Molecular Weight]
403.4 |
| Chemical Properties | Back Directory | [Boiling point ]
706.5±60.0 °C(Predicted) | [density ]
1.447±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
15.53±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
PNU 288034 is an antibacterial agent. | [in vivo]
PNU-288034 is metabolically stable in liver microsomes across species, and unchanged drug is cleared in the urine by an apparent active renal secretion process in rat and monkey. Coadministration of PNU-288034 and the OAT3 inhibitor probenecid significantly increases PNU-288034 plasma area under the curve (170%) and reduces both plasma and renal clearance in monkey. Coadministration of PNU-288034 and cimetidine also reduces plasma clearance in rat to a rate comparable with probenecid coadministration[1]. | [IC 50]
Oxazolidinone | [storage]
Store at -20°C |
|
|