| Identification | Back Directory | [Name]
4-(Chloromethyl)-1H-imidazole hydrochloride | [CAS]
38585-61-4 | [Synonyms]
4-chloromethyl-imidazolhydrochloride
4-Chloromethy-1H-imidazole Hydrochloride
4-Chloromethy-1(3)H-imidazole Hydrochlorid
4-(Chloromethyl)-1H-imidazole hydrochloride
5-(CHLOROMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE
4-Chloromethyl-1(3)H-imidazole Hydrochloride
1H-IMidazole, 4-(chloroMethyl)-, Monohydrochloride
1H-Imidazole, 5-(chloromethyl)-, hydrochloride (1:1)
1H-Imidazole, 4-(chloromethyl)-, monohydrochloride (9CI) | [Molecular Formula]
C4H6Cl2N2 | [MDL Number]
MFCD08234854 | [MOL File]
38585-61-4.mol | [Molecular Weight]
153.01 |
| Chemical Properties | Back Directory | [Appearance]
Beige Solid | [Melting point ]
1400C | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Ethanol, Methanol, Tetrahydrofuran, Toluene | [form ]
Solid | [color ]
Beige |
| Hazard Information | Back Directory | [Chemical Properties]
Beige Solid | [Uses]
4-Chloromethyl-1H-imidazole Hydrochloride (cas# 38585-61-4) is a compound useful in organic synthesis. | [Synthesis]
(A) Synthesis of 4-(chloromethyl)-1H-imidazole hydrochloride
(1) 2 mL of thionyl chloride was dissolved in 20 mL of toluene followed by the addition of 700 mg of 4-hydroxymethylimidazole hydrochloride. The reaction mixture was heated to the reflux temperature of toluene and maintained for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated to dryness under reduced pressure. 4-(Chloromethyl)-1H-imidazole hydrochloride was finally obtained as a white solid (790 mg, 99% yield). | [References]
[1] Journal of Organic Chemistry, 1990, vol. 55, # 6, p. 1890 - 1901
[2] Patent: US5218115, 1993, A
[3] Journal of Organic Chemistry, 2008, vol. 73, # 21, p. 8591 - 8593
[4] Patent: US4847383, 1989, A
[5] Annales pharmaceutiques francaises, 1998, vol. 56, # 6, p. 250 - 255 |
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