| Identification | Back Directory | [Name]
Triptonide | [CAS]
38647-11-9 | [Synonyms]
PG 492
TRIPTONIDE
NSC 165677
Triptonide USP/EP/BP
14-Deoxy-14-oxotriptolide
Triptolide,14-deoxy-14-oxo
TRIPTONIDE(PRIMARY STANDARD)
Triptonide, 98%, from Peucedanum praeruptorum Dunn
(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-Isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)- | [Molecular Formula]
C20H22O6 | [MDL Number]
MFCD00210566 | [MOL File]
38647-11-9.mol | [Molecular Weight]
358.39 |
| Chemical Properties | Back Directory | [Melting point ]
251～252℃ | [Boiling point ]
581.1±50.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Dichloromethane (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Off-White to Pale Beige | [InChIKey]
SWOVVKGLGOOUKI-PBIZPCRONA-N | [SMILES]
C[C@]12CCC3C(=O)OCC=3[C@]1([H])C[C@@H]1O[C@]31C([C@@]1(C(C)C)O[C@H]1[C@@H]1O[C@]231)=O |&1:1,10,13,15,17,22,23,25,r| |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii. | [Uses]
Triptonide is a Triptolide (T815600) analogue used in the preparation of cytotoxic fluorinated Triptolide. | [Definition]
ChEBI:Triptonide is a diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. It has a role as an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent. It is a cyclic ketone, an organic heteroheptacyclic compound, a diterpene triepoxide and a butenolide. | [in vivo]
Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice[2].
| Animal Model: | Eight-week-old female NOD/SCID mice (18-22 g), with 3 x 107 Raji cells xenograft[2] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneal injection, daily, for 34 days | | Result: | Potently inhibited lymphoma cell growth and tumorigenic capability. |
| [target]
ERK | IL Receptor | GSK-3 | p38MAPK | Wnt/β-catenin | [storage]
Store at -20°C |
|
| Company Name: |
cuicheng bio Gold
|
| Telephone: |
13186333400 |
| Website: |
www.cuichengbio.com/ |
| Company Name: |
AF Biochem Co., Ltd. Gold
|
| Telephone: |
+86-028-60911900 13540204019 |
| Website: |
www.afbiochem.com |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
|