386704-15-0

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386704-15-0 Structure

Identification	Back Directory
[Name] METHYL6-(TRIFLUOROMETHYL)NICOTINOYLACETATE
[CAS] 386704-15-0
[Synonyms] 11β-HSD1-IN-8 Methyl 3-oxo-3-(6-(tri?uoromethyl)pyrid in-3-yl)propanoate Methyl 3-oxo-3-[6-(trifluoroMethyl)pyridin-3-yl]propanoate Methyl3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propanoate97% Methyl 3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propanoate 97% 3-Pyridinepropanoic acid, β-oxo-6-(trifluoromethyl)-, methyl ester 3-oxo-3-[6-(trifluoromethyl)-3-pyridinyl]propanoic acid methyl ester Methyl 3-oxo-3-[6-(trifluoromethyl)pyridin-3-yl]propionate, Methyl [6-(trifluoromethyl)nicotinoyl]acetate
[Molecular Formula] C10H8F3NO3
[MDL Number] MFCD01862654
[MOL File] 386704-15-0.mol
[Molecular Weight] 247.17

Chemical Properties	Back Directory
[Melting point ] 60-62°C
[storage temp. ] Inert atmosphere,Room Temperature
[form ] Solid
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Uses] 11β-HSD1-IN-8 (compound c6a) is a 11β HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline[1].
[References] [1] Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268. DOI:10.1038/s41598-022-18740-5

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