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387350-39-2

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387350-39-2 Structure

387350-39-2 Structure
IdentificationBack Directory
[Name]

3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE
[CAS]

387350-39-2
[Synonyms]

Desvenlafaxine Succinate Acid
6-(trifluoromethyl)-3-Pyridinemethanamine
3-(Aminomethyl)-6-(trifluoromethyl)pyridine
5-(Aminomethyl)-2-(trifluoromethyl)pyridine
3-Pyridinemethanamine, 6-(trifluoromethyl)-
(6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)METHANAMINE
C-(6-TrifluoroMethyl-pyridin-3-yl)-MethylaMine
5-(Aminomethyl)-2-(trifluoromethyl)pyridine96%
3-(Aminomethyl)-6-(trifluoromethyl)pyridineHCl
5-(Aminomethyl)-2-(trifluoromethyl)pyridine 97%
3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
[6-(Trifluoromethyl)pyridin-3-yl]methylamine, 6-(Trifluoromethyl)nicotinylamine
[Molecular Formula]

C7H7F3N2
[MDL Number]

MFCD01862649
[MOL File]

387350-39-2.mol
[Molecular Weight]

176.14
Questions And AnswerBack Directory
[Preparation]

Lithium aluminum hydride (LAH, 0.54 g, 14.2 mmol) was added to a tetrahydrofuran solution of 5-(azidomethyl)-2-(trifluoromethyl)pyridine (2.6 g, 12.86 mmol) at -78 °C. The resulting mixture was stirred for 15 minutes, then heated to room temperature and reacted for another hour. The reaction was then quenched with a saturated aqueous solution of ammonium chloride, and stirred for several hours. Anhydrous sodium sulfate was added to the system to separate the two phases into clear layers. The residue was washed with ethyl acetate after filtration. The organic phases were combined and concentrated to give 3-aminomethyl-6-(trifluoromethyl)pyridine.
Chemical PropertiesBack Directory
[Boiling point ]

62-64°C/0.5mm
[density ]

1.293±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,2-8°C
[form ]

liquid
[pka]

7.85±0.29(Predicted)
[color ]

Clear, almost colourless
[InChI]

InChI=1S/C7H7F3N2/c8-7(9,10)6-2-1-5(3-11)4-12-6/h1-2,4H,3,11H2
[InChIKey]

XPXVAYGVYBQKDE-UHFFFAOYSA-N
[SMILES]

C1=NC(C(F)(F)F)=CC=C1CN
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)
GHS05
[Signal word ]

Danger
[Hazard statements ]

H314-H318
[Precautionary statements ]

P280-P301+P330+P331-P302+P352-P304+P340-P305+P351+P338-P310
[Hazard Codes ]

T+
[Risk Statements ]

28-37/38-41-43
[Safety Statements ]

26-28-36/37-39-45
[RIDADR ]

UN2735
[HazardClass ]

8
[HS Code ]

2933399990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Pyridine-->Methyl fluoride
[Preparation Products]

Milademetan-->NUTLIN-3-->[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]methanone
Hazard InformationBack Directory
[Uses]

3-Aminomethyl-6-(trifluoromethyl)pyridine is an important heterocyclic intermediate in the field of drug synthesis, mainly used in the synthesis of antimalarial drugs, kinase inhibitors, anti-inflammatory drugs, etc.
Spectrum DetailBack Directory
[Spectrum Detail]

3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE(387350-39-2)1HNMR
3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE(387350-39-2)1HNMR
3-AMINOMETHYL-6-(TRIFLUOROMETHYL)PYRIDINE(387350-39-2)19FNMR
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