| Identification | Back Directory | [Name]
Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI) | [CAS]
39023-73-9 | [Synonyms]
NHC-diphosphate
Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI) | [Molecular Formula]
C9H15N3O12P2 | [MDL Number]
MFCD32874153 | [MOL File]
39023-73-9.mol | [Molecular Weight]
419.18 |
| Chemical Properties | Back Directory | [density ]
2.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [form ]
Solid | [pka]
1.39±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : 160 mg/mL (381.70 mM) |
| Hazard Information | Back Directory | [Uses]
NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication?of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV)? and hepatitis C virus?(HCV)[1]. | [References]
[1] Brenda I Hernandez-Santiago, et al. Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrob Agents Chemother. 2004 Dec;48(12):4636-42 DOI:10.1128/AAC.48.12.4636-4642.2004
[2] Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. DOI:10.1128/AAC.02395-16 |
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