39136-63-5

16927-13-2

17356-08-0

39136-63-5

General procedure for the synthesis of 2-amino-5-phenylthiazole from 2-bromo-2-phenylacetaldehyde and compound (CAS: 17356-08-0): in Example 17, compound 16 (3.0 g, 15.05 mmol) was added to an ethanol suspension of thiourea (1.4 g, 18.10 mmol). The reaction mixture was heated to reflux for 8 hours. After completion of the reaction, it was cooled to room temperature and concentrated to remove the solvent. The residue was purified by column chromatography through a solvent mixture of dichloromethane (DCM) and methanol (MeOH) to afford the target product 17 as a yellow solid (2.3 g, 80% yield). The structure of the product was characterized by 1H NMR (400 MHz, DMSO-d6) and ESI-MS: 1H NMR δ 9.37 (broad single peak, 2H, NH2), 7.82 (single peak, 1H, Ar-H), 7.58-7.34 (multiple peaks, 6H, Ar-H); ESI-MS: (C9H8N2S) Calculated value 176, measured value 177 [M + H].