| Identification | Back Directory | [Name]
5-phenylthiazol-2-amine | [CAS]
39136-63-5 | [Synonyms]
Einecs 254-312-9
2-AMino-5-phenylthiazol
5-phenylthiazol-2-amine
5-Phenyl-2-thiazolamine
5-Phenylthiazole-2-amine
2-Amino-5-phenylthiazole
2-Thiazolamine, 5-phenyl- | [EINECS(EC#)]
254-312-9 | [Molecular Formula]
C9H8N2S | [MDL Number]
MFCD00022451 | [MOL File]
39136-63-5.mol | [Molecular Weight]
176.24 |
| Chemical Properties | Back Directory | [Melting point ]
256-257℃ | [Boiling point ]
363.4±11.0 °C(Predicted) | [density ]
1.261 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
4.63±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow powder | [Synthesis]
General procedure for the synthesis of 2-amino-5-phenylthiazole from 2-bromo-2-phenylacetaldehyde and compound (CAS: 17356-08-0): in Example 17, compound 16 (3.0 g, 15.05 mmol) was added to an ethanol suspension of thiourea (1.4 g, 18.10 mmol). The reaction mixture was heated to reflux for 8 hours. After completion of the reaction, it was cooled to room temperature and concentrated to remove the solvent. The residue was purified by column chromatography through a solvent mixture of dichloromethane (DCM) and methanol (MeOH) to afford the target product 17 as a yellow solid (2.3 g, 80% yield). The structure of the product was characterized by 1H NMR (400 MHz, DMSO-d6) and ESI-MS: 1H NMR δ 9.37 (broad single peak, 2H, NH2), 7.82 (single peak, 1H, Ar-H), 7.58-7.34 (multiple peaks, 6H, Ar-H); ESI-MS: (C9H8N2S) Calculated value 176, measured value 177 [M + H]. | [References]
[1] Patent: WO2010/144394, 2010, A1. Location in patent: Page/Page column 69
[2] Patent: WO2010/144550, 2010, A1. Location in patent: Page/Page column 68
[3] Patent: WO2015/138895, 2015, A1. Location in patent: Paragraph 000319
[4] Patent: WO2008/144767, 2008, A1. Location in patent: Page/Page column 111 |
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