| Identification | Back Directory | [Name]
2,4-DICHLORO-6-METHYLQUINAZOLINE | [CAS]
39576-82-4 | [Synonyms]
EOS-60385
2,4-DICHLORO-6-METHYLQUINAZOLINE
6-Methyl-2,4-dichloroquinazoline
Quinazoline, 2,4-dichloro-6-methyl-
2,4-Dichloro-6-methylquinazoline,97%
2,4-Dichloro-6-methylquinazoline 97% | [Molecular Formula]
C9H6Cl2N2 | [MDL Number]
MFCD10697888 | [MOL File]
39576-82-4.mol | [Molecular Weight]
213.07 |
| Chemical Properties | Back Directory | [Boiling point ]
292.4±33.0 °C(Predicted) | [density ]
1.418±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
-0.30±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
6-Methylquinazoline-2,4(1H,3H)-dione (550 mg, 3.12 mmol) was used as a starting material, which was dissolved in POCl3 (4.0 mL), followed by the addition of N,N'-diethylaniline (0.5 mL). The reaction mixture was heated to 135 °C and the reaction was stirred at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The precipitated solid was collected by filtration and dried to afford 2,4-dichloro-6-methylquinazoline (590 mg, 89% yield), which could be used in subsequent steps without further purification. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132
[3] Patent: WO2004/87680, 2004, A1. Location in patent: Page 162
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 308 - 312
[5] Patent: WO2008/16666, 2008, A2. Location in patent: Page/Page column 49 |
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| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
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