| Identification | Back Directory | [Name]
(E)-cyclooct-4-enol / axial - TCO4 / A | [CAS]
39637-78-0 | [Synonyms]
(R)-TCO-OH
(R)-Cyclooct-4-en-1-ol
4-Cycloocten-1-ol, (1R)-
(E)-cyclooct-4-enol / axial - TCO / A
(E)-cyclooct-4-enol / axial - TCO4 / A | [Molecular Formula]
C8H14O | [MOL File]
39637-78-0.mol | [Molecular Weight]
126.2 |
| Hazard Information | Back Directory | [Uses]
(R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. (R)-TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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