| Identification | Back Directory | [Name]
1-Oxa-8-azaspiro[4.5]decane, hydrochloride | [CAS]
3970-79-4 | [Synonyms]
1-Oxa-8-azaspiro[4.5]deca...
1-oxa-8-azaspiro[4.5]decane hcl
1-Oxa-8-azaspiro[4.5]decane heMioxalate
8-Aza-1-oxaspiro[4.5]decane hydrochloride
4-Oxa-8-azaspiro[4.5]decane hydrochloride
1-Oxa-8-azaspiro[4.5]decane, hydrochloride
1-oxa-8-azaspiro[4.5]decane hydrochloride (1:1) | [Molecular Formula]
C8H16ClNO | [MDL Number]
MFCD11042294 | [MOL File]
3970-79-4.mol | [Molecular Weight]
177.67 |
| Hazard Information | Back Directory | [Synthesis]
A methanolic hydrogen chloride solution (3M, 20 mL) was slowly added dropwise over 10 minutes to a stirred solution of tert-butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate (3.18 g, 13.2 mmol) in methanol (10 mL) at 0 °C. After dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 1-oxa-8-azaspiro[4.5]decane hydrochloride (2.29 g, 98% yield) as a white solid. Mass spectrometric analysis (ES+) showed m/z 142 ([M+H]+). | [References]
[1] Patent: US2003/236250, 2003, A1. Location in patent: Page 29
[2] Patent: WO2004/78750, 2004, A1. Location in patent: Page 78 |
|
|