| Identification | Back Directory | [Name]
16,16-DIMETHYL PROSTAGLANDIN F2ALPHA | [CAS]
39746-23-1 | [Synonyms]
YMRWVEHSLXJOCD-SCOYTADVSA-N
16,16-dimethylprostaglandin F2A
16,16-dimethyl Prostaglandin F2α
16,16-dimethyl Prostaglandin F2α
16,16-DIMETHYL PROSTAGLANDIN F2ALPHA
9ALPHA,11ALPHA,15R-TRIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID | [Molecular Formula]
C22H38O5 | [MDL Number]
MFCD00135251 | [MOL File]
39746-23-1.mol | [Molecular Weight]
382.53 |
| Chemical Properties | Back Directory | [Fp ]
-13 °C | [storage temp. ]
-20°C | [solubility ]
10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: >10 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
16,16-Dimethylprostaglandin F2α (16,16-Dimethyl-PGF2α) is a potent analog of PGF2α (HY-12956), which exhibits similar binding potency as PGF2α does. 16,16-Dimethylprostaglandin F2α serves as a bronchoconstrictor[1][2]. | [in vivo]
16,16-Dimethylprostaglandin F2α (0-0.5 μg, iv, single dose) inhibits histamine-induced intracheal insufflation pressure increase in guinea pigs model. | Animal Model: | guinea pigs model[1] | | Dosage: | 0-0.5 μg | | Administration: | iv, single dose | | Result: |
Inhibited histamine-induced increase in tracheal insufflation pressure. |
| [References]
[1] Strandberg K, et al., Bronchial effects of some prostaglandin E and F analogues. Acta Physiol Scand. 1977 Jun;100(2):172-81. DOI:10.1111/j.1748-1716.1977.tb05934.x
[2] Balapure AK, et al., Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochem Pharmacol. 1989 Jul 15;38(14):2375-81. DOI:10.1016/0006-2952(89)90478-4 |
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