| Identification | Back Directory | [Name]
JNJ 5207852 dihydrochloride | [CAS]
398473-34-2 | [Synonyms]
JNJ 5207852
JNJ 5207852 dihydrochloride
1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine
1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE
Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-
1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride | [Molecular Formula]
C20H32N2O | [MDL Number]
MFCD05974930 | [MOL File]
398473-34-2.mol | [Molecular Weight]
316.48 |
| Chemical Properties | Back Directory | [Boiling point ]
443.4±30.0 °C(Predicted) | [density ]
1.032±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO : 77.5 mg/mL (244.88 mM; Need ultrasonic) | [form ]
Powder | [pka]
9.70±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
JNJ 5207852 is a Histamine H3 Receptor antagonist, used in the treatment of obesity. | [in vivo]
JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1]. | Animal Model: | Male, Sprague-Dawley rats weighing 282-334 g[1].
| | Dosage: | 3, 10, 30 mg/kg. | | Administration: | S.C. | | Result: | Iincreased time spent awake and decreased REM sleep and slow-wave sleep. |
| [IC 50]
H3 receptor: 8.9 (pKi, for rat); H3 receptor: 9.24 (pKi, for human) |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
|