| Identification | Back Directory | [Name]
31C | [CAS]
398515-96-3 | [Synonyms]
31C
III-31-C
WPE-III-31C
III-31-C >=98% (HPLC), solid
GAMMA-SECRETASE INHIBITOR XVII
N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester
L-Valine, N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-, methyl ester | [Molecular Formula]
C35H52N4O7 | [MDL Number]
MFCD04974985 | [MOL File]
398515-96-3.mol | [Molecular Weight]
640.81 |
| Chemical Properties | Back Directory | [Boiling point ]
832.6±65.0 °C(Predicted) | [density ]
1.135±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: ≥9mg/mL | [form ]
solid | [pka]
12.04±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits A? production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1]. | [Biological Activity]
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor th at binds to γ-secretase at the substrate docking site. DAPTalso a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors th at affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteinsnicastrinAph-1 and Pen-2. | [References]
[1] Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. DOI:10.1074/jbc.C300019200 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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