| Identification | Back Directory | [Name]
4-(cyclohexyloxy)aniline | [CAS]
39905-48-1 | [Synonyms]
AKOS DM0070
4-(cyclohexyloxy)aniline
p-(Cyclohexyloxy)aniline
4-(Cyclohexyloxy)benzenamine
4-(Cyclohexyloxy)phenylamine
Benzenamine, 4-(cyclohexyloxy)- | [Molecular Formula]
C12H17NO | [MDL Number]
MFCD00457982 | [MOL File]
39905-48-1.mol | [Molecular Weight]
191.27 |
| Chemical Properties | Back Directory | [Boiling point ]
101-102℃ (0.05 Torr) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [Appearance]
Light brown to brown Liquid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 45, p. 2260, 2002 DOI: 10.1021/jm010261z | [Synthesis]
General procedure for the synthesis of 4-cyclohexyl ether-aniline from bromocyclohexane and 1-(cyclohexyloxy)-4-nitrobenzene (CAS: 5493-73-2): to a stirring solution of 1-(cyclohexyloxy)-4-nitrobenzene (1 g) in methanol (15 mL) under nitrogen protection was added 10% Pd/C (0.721 g). The reaction mixture was stirred under a hydrogen atmosphere (using a hydrogen balloon) for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give the target product 4-cyclohexyl ether-aniline (700 mg). The product was analyzed by LCMS, m/z 192.1 (M + H)+. | [References]
[1] Patent: WO2017/153952, 2017, A1. Location in patent: Page/Page column 147 |
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