| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO | [form ]
Solid | [color ]
White to off-white | [Appearance]
white solid | [Optical Rotation]
[α]/D -15±3°, c = 1 in H2O | [BRN ]
4145305 | [InChI]
1S/C17H33NO4/c1-5-6-7-8-9-10-11-12-17(21)22-15(13-16(19)20)14-18(2,3)4/h15H,5-14H2,1-4H3/t15-/m1/s1 | [InChIKey]
LZOSYCMHQXPBFU-OAHLLOKOSA-N | [SMILES]
C[N+](C)(C)C[C@H](OC(CCCCCCCCC)=O)CC([O-])=O |
| Hazard Information | Back Directory | [Description]
Decanoylcarnitine is a decanoic acid ester of carnitine. Decanoylcarnitine bis a medium-chain acylcarnitine that may facilitate the transport of long-chain fatty acids into the mitochondria where fatty acids undergo β-oxidation. Decanoylcarnitine is used as an analytical reference standard using GC- or LC-MS methods.
Decanoylcarnitine serves as a specific diagnostic biomarker for metabolites found in medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, especially in neonates, glutaric acidemia type II, celiac disease, and adolescent obesity. Secondary marker of medium-chain ketoacyl-CoA thiolase deficiency.
The product is used primarily as a control for MS/MS. | [Uses]
Decanoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in the following:
- In dried blood spots using chip-based nanoelectrospray source coupled with high resolution mass spectrometry (chip-based nanoESI- HRMS) and targeted liquid chromatography-tandem mass spectrometry (LC/MS/MS).
- In biological samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC/MS/MS).
| [Definition]
ChEBI: O-decanoyl-L-carnitine is an O-acyl-L-carnitine that is L-carnitine having decanoyl as the acyl substituent. It has a role as a human metabolite. It is an O-decanoylcarnitine and a saturated fatty acyl-L-carnitine. | [General Description]
Decanoyl-L-carnitine, belonging to the class of acylcarnitines, serves as a specific diagnostic metabolite biomarker, found in medium-chain acyl CoA dehydrogenase (MCAD) deficiency especially in newborns. | [Biochem/physiol Actions]
Decanoylcarnitine is useful in the diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency deficiencyoxidation disorders. |
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| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|