| Identification | Back Directory | [Name]
ETIZOLAM | [CAS]
40054-69-1 | [Synonyms]
depas
azepin
Y-7131
ahr3219
Etizola
ETIZOLAM
Brn 0572740
hyl-9-methyl-
Etizolam solution
Sedekopan ada@tuskwei.com
Etizolam lila@tuskwei.com
4-c)thieno(2,3-e)(1,4)-diazepine,6-(o-chlorophenyl)-8-ethyl-1-4h-s-triazolo(
6-(o-chlorophenyl)-8-ethyl-1-methyl-4h-s-triazolo(3,4-c)thieno(2,3-e)(1,4)-d
6-(o-chlorphenyl)-8-aethyl-1-methyl-4h-s-triazolo(3,4-c)thieno(2,3-e)(1,4)di
6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine,4-(2-chlorophenyl)-2-et
8-ethyl-6-(o-chlorophenyl)-1-methyl-4h-s-triazolo(3,4c)thieno(2,3e)-1,4-diaz
8-Ethyl-6-(o-chlorophenyl)-1-methyl-4H-S-triazolo(3,4C)thieno(2,3E)-1,4-diazepine
6-(o-Chlorphenyl)-8-aethyl-1-methyl-4H-S-triazolo(3,4-C)thieno(2,3-E)(1,4)diazepin
6-(o-Chlorophenyl)-8-ethyl-1-methyl-4H-S-triazolo(3,4-C)thieno(2,3-E)(1,4)-diazepine
4-(o-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno(3,2-F)-S-triazolo(4,3-A)(1,4)diazepine
4H-S-Triazolo(3,4-C)thieno(2,3-E)(1,4)-diazepine, 6-(o-chlorophenyl)-8-ethyl-1-methyl-
4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
4-(o-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
6H-Thieno(3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine, 4-(2-chlorophenyl)-2-ethyl-9-methyl-
6-(o-Chlorphenyl)-8-aethyl-1-methyl-4H-S-triazolo(3,4-C)thieno(2,3-E)(1,4)diazepin [german] | [EINECS(EC#)]
662-368-4 | [Molecular Formula]
C17H15ClN4S | [MDL Number]
MFCD00867532 | [MOL File]
40054-69-1.mol | [Molecular Weight]
342.85 |
| Chemical Properties | Back Directory | [Melting point ]
147-148℃ | [Boiling point ]
264.5°C (rough estimate) | [density ]
1.43 | [refractive index ]
1.6100 (estimate) | [Fp ]
9°C | [storage temp. ]
?20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | [form ]
A neat solid | [pka]
2.37±0.40(Predicted) | [CAS DataBase Reference]
40054-69-1 |
| Hazard Information | Back Directory | [Uses]
Etilozam is a a thienodiazepine benzodiazepine derivative, and has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic related to
that of the classic benzodiazepines. Etizolam has effect on monoamine metabolism in brain.
Etilozam can be used for the short-term treatment of insomnia, anxiety or panic attacks. | [Uses]
Nasal Dilator | [Originator]
Yoshitomi (Japan) | [Definition]
ChEBI: Etizolam is an organic molecular entity. | [Brand name]
DEPAS |
| Safety Data | Back Directory | [Hazard Codes ]
F,T | [Risk Statements ]
11-23/24/25-39/23/24/25 | [Safety Statements ]
7-16-36/37-45 | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
1 | [Toxicity]
LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari) |
| Questions And Answer | Back Directory | [Description]
Etizolam is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety or panic attacks. It has amnesic, anxiolytic, anticonvulsant, and hypnotic, sedative and skeletal muscle relaxant properties. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system.
| [References]
https://www.drugbank.ca/drugs/DB09166
https://en.wikipedia.org/wiki/Etizolam
Casacchia, Massimo, F. Bolino, and U. Ecari. "Etizolam in the treatment of generalized anxiety disorder: a double-blind study versus placebo."Current Medical Research & Opinion 12.4(2008):215-223.
Savoldi, F, G. Somenzini, and U. Ecari. "Etizolam versus placebo in the treatment of panic disorder with agoraphobia: a double-blind study."Current Medical Research & Opinion 12.3(1990):185.
Hirashima, Y, et al. "Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography." Neurologia medico-chirurgica 42.2(2002):53-55.
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