| Identification | Back Directory | [Name]
JNJ 10329670 | [CAS]
400797-24-2 | [Synonyms]
JNJ 10329670
JNJ10329670,JNJ 10329670
2H-Benzimidazol-2-one, 5-chloro-1,3-dihydro-1-methyl-3-[1-[3-[4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[4,3-c]pyridin-1-yl]propyl]-4-piperidinyl]- | [Molecular Formula]
C30H34ClF3N6O3S | [MOL File]
400797-24-2.mol | [Molecular Weight]
651.14 |
| Hazard Information | Back Directory | [Uses]
JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. JNJ 10329670 blocks invariant chain proteolysis in B cells and dendritic cells, as well as antigen-induced T cell proliferation[1]. | [IC 50]
cathepsin S: 34 nM (Ki) | [References]
[1] Thurmond RL, et, al. Identification of a potent and selective noncovalent cathepsin S inhibitor. J Pharmacol Exp Ther. 2004 Jan;308(1):268-76. DOI:10.1124/jpet.103.056879 |
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