| Identification | Back Directory | [Name]
2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBOXAMIDE | [CAS]
40106-12-5 | [Synonyms]
NSC727447
2-Amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophene-3-carboxamide | [Molecular Formula]
C10H14N2OS | [MDL Number]
MFCD00622214 | [MOL File]
40106-12-5.mol | [Molecular Weight]
210.3 |
| Chemical Properties | Back Directory | [Melting point ]
154-156 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
347.5±42.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >10mg/mL | [form ]
Solid | [pka]
15.70±0.20(Predicted) | [color ]
Light brown to brown | [InChI]
1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13) | [InChIKey]
LULYZYNTDPUEKK-UHFFFAOYSA-N | [SMILES]
NC(=O)c1c(N)sc2CCCCCc12 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Uses]
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1]. | [Biological Activity]
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase Hbut gre at selectivity over human Rnase H. | [References]
[1] Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3(10):635-44. DOI:10.1021/cb8001039 |
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Merck KGaA
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Carbosynth
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www.carbosynth.com |
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