| Identification | Back Directory | [Name]
Quinuclidine-4-carboxylic acid hydrochloride | [CAS]
40117-63-3 | [Synonyms]
Quinuclidine-4-carboxylic...
Umeclidinium Bromide Impurity 7 HCl
Quinuclidine-4-carboxylic acid hydrochloride
1-aza-bicyclo[2.2.2]octane-4-carboxylic acid hcl
1-azabicyclo[2.2.2]octane-4-carboxylic acid hydrochloride
1-Azabicyclo[2.2.2]octane-4-carboxylic acid, hydrochloride (1:1) | [Molecular Formula]
C8H14ClNO2 | [MDL Number]
MFCD19686936 | [MOL File]
40117-63-3.mol | [Molecular Weight]
191.655 |
| Chemical Properties | Back Directory | [Melting point ]
>360 °C(Solv: ethanol (64-17-5)) | [storage temp. ]
Inert atmosphere,Room Temperature | [Appearance]
White to light yellow Solid | [InChI]
InChI=1S/C8H13NO2.ClH/c10-7(11)8-1-4-9(5-2-8)6-3-8;/h1-6H2,(H,10,11);1H | [InChIKey]
JTYXRFSULOZNPH-UHFFFAOYSA-N | [SMILES]
N12CCC(C(O)=O)(CC1)CC2.[H]Cl |
| Hazard Information | Back Directory | [Uses]
4-Quinuclidinecarboxylic Acid Hydrochloride is a useful research chemical compound used in the of pleuromutilin derivatives as antimicrobials. | [Synthesis]
General procedure for the synthesis of 1-azabicyclo[2.2.2]octane-4-carboxylic acid hydrochloride from 4-cyanoquinuclidine: Quinuclidine-4-carbonitrile (4 g, 29.4 mmol) was dissolved in 30 mL of aqueous 6N hydrochloric acid and the reaction was stirred under refluxing conditions for 16 hours. Upon completion of the reaction, the reaction mixture was cooled and subsequently evaporated to dryness under reduced pressure. The resulting solid was ground with 20% ether-hexane mixture to give the final quinuclidine-4-carboxylic acid hydrochloride (5.5 g, quantitative yield). | [References]
[1] Patent: US2016/9706, 2016, A1. Location in patent: Paragraph 0193 |
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