| Identification | Back Directory | [Name]
TICRYNAFEN | [CAS]
40180-04-9 | [Synonyms]
ce3624
fr3068
ticrex
anp3624
Tienilic
selacryn
skf62698
diflurex
Difluorex
tienilicacid
thienylicacid
Tienylic acid
TIENILIC ACID(TICRYNAFEN)
4-(2-theonyl)-2,3-dichlorphenoxyessigsaeure
4-(2-Thenoyl)-2,3-dichlorophenoxyacetic Acid
(2,3-dichloro-4-(2-thenoyl)phenoxy)aceticacid
4-(2-thienylketo)-2,3-dichlorophenoxyaceticacid
4-(2-Thienylcarbonyl)-2,3-dichlorophenoxyacetic acid
(2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-aceticaci
(2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)aceticacid
(2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy)aceticacid
2-[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid
Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-
2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid
2-{2,3-dichloro-4-[(thiophen-2-yl)carbonyl]phenoxy}acetic acid
[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]aceticAcid,TienilicAcid,ThienylicAcid,ANP-3624,CE-3624,SKF-62698,Dif
[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid, Tienilic Acid, Thienylic Acid, ANP-3624, CE-3624, SKF-62698, Diflurex, Selacryn | [EINECS(EC#)]
254-826-3 | [Molecular Formula]
C13H8Cl2O4S | [MDL Number]
MFCD00867339 | [MOL File]
40180-04-9.mol | [Molecular Weight]
331.17 |
| Chemical Properties | Back Directory | [Appearance]
Pale Beige Solid | [Melting point ]
148-149oC | [Boiling point ]
534.6±50.0 °C(Predicted) | [density ]
1.532 | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO: soluble5mg/mL (clear solution) | [form ]
powder | [pka]
2.79±0.10(Predicted) | [color ]
white to beige | [InChI]
InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17) | [InChIKey]
AGHANLSBXUWXTB-UHFFFAOYSA-N | [SMILES]
C(O)(=O)COC1=CC=C(C(C2SC=CC=2)=O)C(Cl)=C1Cl |
| Hazard Information | Back Directory | [Description]
Cytochrome P450 enzymes function to metabolize both endogenous and exogenous compounds. Both the 3A and 2C isoforms are present in human liver of which CYP2C9 seems most highly expressed.1 Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates the enzyme.2,3 The time required to inactivate one half of the CYP2C10 enzyme at the maximal rate (t½max) is 3.4 minutes, with a dissociation constant (KI) value of 4.3 μM.3 | [Chemical Properties]
Pale Beige Solid | [Uses]
A heterocycloc derivative of phenoxyacetic Acid. Uses as a diuretic, uricosuric, anhtihypertensive | [Uses]
Tienilic Acid is a heterocyclic derivative of phenoxyacetic acid. Tienilic acid is used as diuretic, uricosuric, antihypertensive. | [Definition]
ChEBI: An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links wi
h hepatitis. | [Brand name]
Tienilic Acid is INN and BAN;Anp 3624;Diflarex;Fr 3068;Selcryn;Skf-62698;Ticrynafen;Ticrynapen. | [World Health Organization (WHO)]
Tienilic acid, a diuretic agent with uricosuric and antihypertensive
activity, was introduced in 1976. By 1979 its use had been associated with cases of
hepatic toxicity, some of which were fatal, which led to the withdrawal of the drug
in most countries in which it was marketed. In France, however, precautions
regarding the use of tienilic acid were issued by the Pharmacovigilance
Commission and the drug remained available for another decade. In 1991, it was
eventually also withdrawn there since cases of hepatitis, some of which were
fulminant, had continued to occur. | [Biochem/physiol Actions]
Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity. | [Synthesis]
Ticrynafen was prepared as follows: to the reaction flask were added 1092g (4.0 mol) of 2,3-dichloro-4-hydroxyphenyl-2-thienyl ketone, 160g (4.0 mol) of sodium hydroxide powder, 100g of sodium iodide granules and 1400 mL of water. The mixture was heated t | [References]
[1] ANNAH MANCY. The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling[J]. Biochemistry Biochemistry, 1995, 34 33: 10365-10375. DOI: 10.1021/bi00033a007
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] M. PILAR LOPEZ-GARCIA Daniel M Patrick M Dansette. Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid[J]. Biochemistry Biochemistry, 1994, 33 1: 166-175. DOI: 10.1021/bi00167a022 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
DebyeTec.com Inc.
|
| Telephone: |
18086626237 18086626237 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList16955/0.htm |
| Company Name: |
parabiochem
|
| Telephone: |
025-83453382-8005 |
| Website: |
www.parabiochem.cn |
|