| Identification | Back Directory | [Name]
AC-LEU-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID) | [CAS]
402832-01-3 | [Synonyms]
AC-LEU-GLU-VAL-ASP-ALDEHYDE (PSEUDO ACID)
L-Valinamide, N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- | [Molecular Formula]
C22H36N4O9 | [MDL Number]
MFCD03788105 | [MOL File]
402832-01-3.mol | [Molecular Weight]
500.55 |
| Chemical Properties | Back Directory | [Boiling point ]
914.6±65.0 °C(Predicted) | [density ]
1.238±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 0°C | [solubility ]
water: 1 mg/mL | [form ]
lyophilized solid | [pka]
4.19±0.10(Predicted) | [color ]
white | [Water Solubility ]
water: 1mg/mL | [Sequence]
Ac-Leu-Glu-Val-Asp-CHO | [InChIKey]
MXGJLIBJKIIQSF-FPXQBCRKSA-N | [SMILES]
N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O |
| Hazard Information | Back Directory | [Uses]
Ac-LEVD-CHO is a caspase-4 inhibitor. Ac-LEVD-CHO is a peptide with the sequence of Ac-Leu-Glu-Val-Asp-al[1]. | [Biological Activity]
Cell permeable: no''Primary Target
caspase-4''Product does not compete with ATP.''Reversible: yes | [IC 50]
Caspase-4 | [References]
[1] Hye-Kyoung Jun, et al. Treponema denticola, Porphyromonas gingivalis, and Tannerella forsythia induce cell death and release of endogenous danger signals. Arch Oral Biol. 2017, 72, 73. DOI:10.1016/j.archoralbio.2016.09.010 |
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