| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl- | [CAS]
40313-92-6 | [Synonyms]
Thalidomide-5-methyl
2-(2,6-Dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-methyl-
2-(2,6-dioxopiperidin-3-yl)-5-methyl-2,3-dihydro-1
H-isoindole-1,3-dione
Thalidomide 5 methyl,inhibit,E3 ligase-recruiting Moiety,Thalidomide5methyl,Ligands for E3 Ligase,Inhibitor | [Molecular Formula]
C14H12N2O4 | [MOL File]
40313-92-6.mol | [Molecular Weight]
272.26 |
| Chemical Properties | Back Directory | [Melting point ]
265.5-267.5 °C(Solv: methanol (67-56-1)) | [Boiling point ]
531.6±50.0 °C(Predicted) | [density ]
1.448±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.73±0.40(Predicted) | [color ]
Gray to gray purple |
| Hazard Information | Back Directory | [Uses]
Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1]. | [IC 50]
Cereblon | [References]
[1] George W. Muller, et al. Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels. Patent US5874448A. |
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| Company Name: |
Pharmalego
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| Tel: |
18321033991 |
| Website: |
https://cn.pharmalego.com/ |
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