| Identification | Back Directory | [Name]
CHEMBRDG-BB 9072017 | [CAS]
40353-62-6 | [Synonyms]
CHEMBRDG-BB 9072017
1-(2-Amino-5-methyl-4-thiazolyl)etha
1-(2-aMino-5-Methylthiazol-4-yl)ethanone
1-(2-Amino-5-methyl-4-thiazolyl)ethanone
Ethanone, 1-(2-amino-5-methyl-4-thiazolyl)-
1-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ETHANONE
1-(2-amino-5-methyl-1,3-thiazol-4-yl)ethanone 1HCl
1-(2-amino-5-methyl-1,3-thiazol-4-yl)ethanone(SALTDATA: HCl) | [Molecular Formula]
C6H8N2OS | [MDL Number]
MFCD08692000 | [MOL File]
40353-62-6.mol | [Molecular Weight]
156.21 |
| Chemical Properties | Back Directory | [Boiling point ]
312.8±22.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
2.89±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Uses]
1-(2-Amino-5-methylthiazol-4-yl)ethanone is a useful research intermediate for the preparation of aminothiazoles. | [Synthesis]
GENERAL METHOD: 4-Bromopentane-2,3-dione (1.79 g, 10.00 mmol) was dissolved in ethanol (50 mL), followed by the addition of thiourea (760 mg, 9.98 mmol). The reaction mixture was stirred at 100 °C for 1 h, after which it was cooled to room temperature. The product was separated by filtration to afford 1-(2-amino-5-methyl-1,3-thiazol-4-yl)ethan-1-one as an off-white solid (1.2 g, 65% yield).LCMS (ESI) analysis showed [M + H]+ = 157.0. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 19, p. 5879 - 5882
[2] Patent: WO2015/52226, 2015, A1. Location in patent: Paragraph 0353
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2760 - 2779 |
|
|