| Identification | Back Directory | [Name]
MET-GLU-HIS-PHE-ARG-TRP-GLY | [CAS]
4037-01-8 | [Synonyms]
MEHFRWG
ACTH (4-10)
a-MSH (4-10)
n-acetyl semax
ACTH (4-10), HUMAN
n-acetyl semax amidate
MET-GLU-HIS-PHE-ARG-TRP-GLY
L-MET-GLU-HIS-PHE-ARG-TRP-GLY
H-MET-GLU-HIS-PHE-ARG-TRP-GLY-OH
ADRENOCORTICOTROPIC HORMONE (4-10)
ACTH (4-10),MET-GLU-HIS-PHE-ARG-TRP-GLY
Adrenocorticotropic Hormone (ACTH) (4-10)
ADRENOCORTICOTROPIC HORMONE (4-10), HUMAN
ADRENOCORTICOTROPIC HORMONE FRAGMENT 4-10
ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 4-10
adrenocorticotropic hormone fragment*4-10 human
Adrenocorticotropic Hormone (ACTH) (4-10), human
adrenocorticotropic hormone fragment 4-10 human, rat
Glycine, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-
ACTH (4-10) trifluoroacetate salt H-Met-Glu-His-Phe-Arg-Trp-Gly-OH trifluoroacetate salt
L-Methionyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-N5-(diaminomethylene)-L-ornithyl-L-tryptophylglycine
(5S,8S,11S,14S,17S)-14-((1H-Imidazol-4-yl)methyl)-5-((1H-indol-3-yl)methyl)-17-((S)-2-amino-4-(methylthio)butanamido)-11-benzyl-8-(3-guanidinopropyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid | [Molecular Formula]
C44H59N13O10S | [MDL Number]
MFCD00167482 | [MOL File]
4037-01-8.mol | [Molecular Weight]
962.09 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [RTECS ]
MC0596950 | [storage temp. ]
−20°C
| [form ]
Solid | [pka]
3.32±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Met-Glu-His-Phe-Arg-Trp-Gly |
| Hazard Information | Back Directory | [Uses]
Adrenocorticotropic Hormone (ACTH) (4-10), human is a melanocortin 4 (MC4R) receptor agonist. | [Biological Activity]
Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 4 receptor (MC4R) agonist. | [in vitro]
Adrenocorticotropic Hormone (ACTH) (4-10), human (ACTH (4-10)) is the core sequence of all melanocortins and binds selectively to MC4-R. In humans, ACTH (4-10) enters the cerebral fluid compartment after intranasal application and leads to a decrease in total body fat after 6 weeks of continuous treatment. | [target]
| [IC 50]
MC4R | [References]
[1] Wellh?ner P, et al. Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue. Int J Obes (Lond). 2012 May;36(5):703-8. DOI:10.1038/ijo.2011.105 |
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