| Identification | Back Directory | [Name]
AC-LEHD-CMK | [CAS]
403848-57-7 | [Synonyms]
AC-LEHD-CMK
AC-LEU-GLU-HIS-ASP-CMK
CASPASE-9 INHIBITOR III
Caspase-9 Inhibitor III(Ac-LEHD-CMK)
AC-LEU-GLU-HIS-ASP-CHLOROMETHYLKETONE
L-Histidinamide, N-acetyl-L-leucyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]- | [Molecular Formula]
C24H35ClN6O9 | [MDL Number]
MFCD02259690 | [MOL File]
403848-57-7.mol | [Molecular Weight]
587.02 |
| Chemical Properties | Back Directory | [Boiling point ]
1113.4±65.0 °C(Predicted) | [density ]
1.362±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
water: 1 mg/mL || DMSO: 5 mg/mL | [form ]
Powder | [pka]
3.91±0.19(Predicted) | [color ]
White to off-white | [Water Solubility ]
water: 1mg/mL
DMSO: 5mg/mL | [InChIKey]
JSRLQUNMFYXVQD-XSLAGTTESA-N | [SMILES]
ClCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O)Cc1nc[nH]c1)CC(=O)O |
| Hazard Information | Back Directory | [Uses]
A potent and irreversible inhibitor of caspase-9 | [Biological Activity]
Cell permeable: yes''Primary Target
caspase-9''Product does not compete with ATP.''Reversible: no''Target IC50: 70 nM against caspase-9 | [IC 50]
Caspase-9 |
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