| Identification | Back Directory | [Name]
N-ETHYL-N-(4-FLUOROPHENYL)AMINE | [CAS]
405-67-4 | [Synonyms]
100156
ethyl(4-fluorophenyl)amine
N-Ethyl-4-fluoro-benzenaMine
BenzenaMine,N-ethyl-4-fluoro- | [Molecular Formula]
C8H10FN | [MDL Number]
MFCD03210682 | [MOL File]
405-67-4.mol | [Molecular Weight]
139.17 |
| Chemical Properties | Back Directory | [Boiling point ]
92 °C(Press: 14 Torr) | [density ]
1.073±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
5.22±0.32(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of N-ethyl-4-fluoroaniline from triethylamine and 4-fluoroaniline is as follows: first, a mixed solution of IrCl3 (2 mol%, 0.02 mmol), ligand L1 (2.4 mol%, 0.024 mmol), sodium hydroxide (0.20 mmol), and xylene (3 mL) was stirred for 1 hr at room temperature in a Schlenk tube . Subsequently, 4-fluoroaniline (1.00 mmol), triethylamine (1.0 mL) and sodium hydroxide (1.00 mmol) were added to the reaction system. The reaction mixture was heated at 150 °C for 20 h, after which it was cooled to room temperature. Upon completion of the reaction, the resulting solution was purified directly by column chromatography using petroleum ether/ethyl acetate (10:1) as eluent to give the final target product N-ethyl-4-fluoroaniline (3a). | [References]
[1] ACS Catalysis, 2014, vol. 4, # 11, p. 3910 - 3918
[2] Tetrahedron Letters, 2016, vol. 57, # 41, p. 4588 - 4591 |
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| Company Name: |
TRUE LABS
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| Tel: |
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| Website: |
www.truelabs.in |
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